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RAS BiologyЦитология Cell and Tissue Biology

  • ISSN (Print) 0041-3771
  • ISSN (Online) 3034-6061

Vimentin in Kolmer cells of spontaneously hypertensive rats

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PII
10.31857/S0041377124010075-1
DOI
10.31857/S0041377124010075
Publication type
Article
Status
Published
Authors
V. A. Razenkova
  • Affiliation: Institute of Experimental Medicine
Volume/ Edition
Volume 66 / Issue number 1
Pages
77-84
Abstract
Epiplexus (Kolmer) cells are macrophage-like cells of the choroid plexus that help maintain the blood-cerebrospinal fluid barrier. Here we studied the structural organization of Kolmer cells in Wistar, Wistar-Kyoto and spontaneously hypertensive (SHR) rats. A comparative study using Iba-1, CD68 and vimentin immunohistochemistry showed that the functional activity of epiplexus cells differs in three examined groups of animals. Wistar-Kyoto and SHR rats showed noticeable signs of Kolmer cells activation, which consisted in the disappearance of cell processes resulting in the formation of round-shaped cells. Another significant observation was the presence of vimentin in activated epiplexus cells. The result obtained indicates that vimentin expression by phagocytic cells could be linked with their activation.
Keywords
клетка Колмера крыса SHR головной мозг сосудистое сплетение иммуногистохимия
Date of publication
15.01.2024
Year of publication
2024
Number of purchasers
0
Views
45

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