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RAS BiologyЦитология Cell and Tissue Biology

  • ISSN (Print) 0041-3771
  • ISSN (Online) 3034-6061

Microvesicles from mesenchymal stem cells for cartilage tissue regeneration in equine osteoarthritis

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PII
10.31857/S0041377124050044-1
DOI
10.31857/S0041377124050044
Publication type
Article
Status
Published
Authors
A. M. Aimaletdinov
  • Affiliation: Kazan (Volga Region) Federal University
Volume/ Edition
Volume 66 / Issue number 5-6
Pages
438-449
Abstract
Current treatment strategies for osteoarthritis primarily focus on symptom management. Currently, the use of cell therapy methods, including mesenchymal stem cells (MSCs), is practiced in medicine and veterinary medicine. Microvesicles (MVs) obtained from MSCs are also currently used for the purpose of regeneration. The purpose of this study was to investigate the potential effects of artificial MVs on rat chondrocytes. In vitro experiments showed that MVs obtained from MSCs had a positive effect on the viability and migration ability of the chondrocyte cell culture. In 3D modeling of OA in vitro, MVs neutralized the effect of pro-inflammatory factors IL-1b and TNF-α. Most likely, these effects were due to the direct penetration of MVs contents into chondrocytes, since the possibility of fusion of MVs membranes with chondrocyte membranes was experimentally demonstrated. Thus, we have shown the positive effect of MVs on an in vitro model of OA.
Keywords
остеоартрит мезенхимные стволовые клетки микровезикулы лошадь хондроциты хрящевая ткань крыса
Date of publication
15.11.2024
Year of publication
2024
Number of purchasers
0
Views
12

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